A tendency toward supra-therapeutic anticoagulation occurred after Ramadan, thus a closer follow up during this period may be reasonable.Īntithrombotic therapy Coumadin International normalized ratio Muslim Prothrombin time.īonow R.O., Carabello B.A., Chatterjee K., de Leon A.C., Jr Faxon D.P., Freed M.D. ![]() No significant difference in mean INR or warfarin dose was found and a better quality of anticoagulation was achieved during Ramadan. A significantly larger ratio of infra-therapeutic INR values was noticed in the pre-Ramadan month (p < 0.05). A significantly larger ratio of supratherapeutic INR values occurred in the post-Ramadan month (p < 0.05). A significantly better quality of anticoagulation was noticed during Ramadan (p < 0.001). Blood osmolarity was significantly lower during Ramadan compared to pre- and post-Ramadan months. The post-Ramadan INR was significantly larger than pre-Ramadan (p = 0.004). No significant difference in INR and warfarin dose was found between Ramadan month, and months before and after it. Patients presented for weekly visits in which blood samples were obtained. To study the impact of Ramadan fasting on international normalized ratio (INR), quality of anticoagulation, dose of warfarin used and blood osmolarity.ġ8 patients were followed-up prospectively for 3 months (pre- Ramadan, Ramadan and post-Ramadan months). The effects of religious fasting during Ramadan month (in the Islamic calendar) on anticoagulation aren't clear. ![]() ![]() Oral anticoagulation with warfarin is indicated for patients with prosthetic heart valves.
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